Bioavailability of CBD Sublingual Use

Various nutrients and compounds are necessary and desirable to generate specific results in the body. These can be anything from medications and vitamins, which stimulate health or even caffeine, sugar and fats. Everything that is taken into the body has some effect. The amount of nutrition gained or effect generated is based on the bioavailability of the compound.

What is Bioavailability?

Bioavailability is a term used in pharmacology, nutritional and environmental sciences referring to the degree and rate at which an administered compound is absorbed by the body’s circulatory system. When a compound is highly bioavailable, the body can absorb a large percentage of it consistently. Method of administration plays a crucial role in bioavailability. Recent years have produced an upward trend in the sublingual administration of compounds due to the high rate of bioavailability it allows. Considered a 100% effective way to receive all of the nutrients available, intravenous administration is the standard measurement for bioavailability. This route of administration is not reasonable for all compounds, nor is it practical for health reasons.

Methods of Administration

Sublingual CBD Applications Receptra Naturals Hemp The most common way to receive substances into the body is through ingestion, aka eating and drinking. It is not always the most efficient method, but the vast majority of our daily intake is processed through this route.

Sublingual Standard

The word “sub” means under. “Lingual” refers to the tongue.” Sublingual administration involves placing a substance under the tongue, allowing it to dissolve and absorb through that tissue. The mucous membranes under the tongue are ideal for absorption due to the large number of capillaries and blood vessels located there. The only risk of degradation prior to entering the bloodstream is the minor effect of salivary enzymes. This direct route foregoes the digestive tract, thus maintaining the efficacy of the compound. Avoiding metabolization in the liver may induce a stronger result with less volume or concentration needed. There are a number of uses for sublingual administration. Some sublingual products include vitamins such as B12 and D3, supplements like melatonin, pain medication, caffeine and even breath mints. CBD sublingual administration is the most effective way to deliver cannabinoids into the bloodstream, though it is not the only way. Receptra Naturals CBD Sublingual

Oral Intake

When you eat, drink or swallow a pill those compounds travel through the entire gastrointestinal tract. This journey starts in the stomach, where acid, bile and other enzymes contribute to the breakdown. Then on to the intestines where absorption takes place, and the liver where metabolization and distribution occur. The effects of the gastrointestinal tract are designed to be harsh. This is the system through which food is broken down and nutrients stripped out. The process is called “first-metabolism.” Compounds make a second pass through the liver before they are eliminated. There are several factors that could impair oral uptake.
  • High water solubility
  • Not dissolving sufficiently
  • Poor digestion
  • Binding to other substances
  • Use by intestinal bacteria

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Breathe it In

Inhalation is also a viable method of to receive compounds into the bloodstream. Lung tissue has high permeability as well as a large, absorptive surface area. The blood supply in the lungs is also sufficient to allow breathable compounds to enter systemic circulation. This makes inhalation a decent option to receive benefits and is generally superior to oral intake, but not as effective as sublingual.

CBD Sublingual Administration

Though edibles infused with CBD oil may be delicious and smoking may be a tradition, CBD sublingual administration provides far more bioavailability. This means that you can take less of the substance sublingually and receive equal or greater effects because the compounds remain intact when entering the bloodstream. For proper CBD sublingual use, place your desired amount of CBD tincture under the tongue and leave it there without swallowing for one to two minutes. The longer you can wait and allow the oil to be absorbed by the mucous membranes under the tongue, the more effective your dose will be.

CBD and Carrier Oils

Co-administration of CBD with medium or long-chain triglycerides (fatty acids) is known to increase bioavailability. This thought to occur because some fatty acids are directly metabolized into energy by the liver, allowing them to quickly disseminate into the bloodstream. Some studies have shown that fatty acids may also work by bypassing the first metabolism. Fatty acids are important even in CBD sublingual administration because of the small percentage of the compound that is not held under the tongue and is instead swallowed. That swallowed CBD oil would normally be subject to the full gastrointestinal process that occurs for oral administration, which causes dilution. Receptra Naturals uses high-quality MCT derived from coconut oil. On its own, MCT oil has been linked to improvements in cognitive function, weight management, and other health benefits. Paired with CBD, MCT oil helps to increase bioavailability. Receptra Naturals Hemp CBD Coconut Oil MCT Oil

Other Applications

Topical CBD

CBD can be used topically. CBD binds to CB2 receptors in the body, inhibiting production of the enzyme that breaks down the neurotransmitter called anandamide. The purpose of anandamide is to block pain receptors. More anandamide equals less pain. Topical applications such as Receptra Targeted Topical address soreness on the surface.

Suppository

Though not common for everyday use, rectal and vaginal suppositories have been introduced onto the market. These methods of administration are varied in bioavailability with home remedies being very low. CBD suppositories were originally developed for their effects on specific rectal and vaginal concerns, but can be used systemically. The most obvious hindrance to this form of CBD administration is awkwardness and inconvenience.

CBD Sublingual is Number One

There are a great many reasons to take CBD oil. Regardless of your individual motive, getting the most out of every dose makes a lot of sense. Using CBD sublingual applications with high-quality tinctures such as Receptra Naturals is the best way to accomplish that purpose.

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